
ALPHA ORAL HEALTH

Introducing Alpha Oral Health, LLC —​an innovative joint venture between Orabio, Inc. and ADA Corporate Ventures, Incorporated. We are dedicated to transforming the treatment of periodontitis. Together, we are pioneering a groundbreaking pharmaceutical technology to revolutionize periodontal care. Backed by the expertise of the renowned ADA Forsyth scientific team, Alpha Oral Health will drive forward all the clinical research and development needed to bring this drug to market. This partnership is set to reshape oral health care, providing advanced solutions to those affected by periodontitis and setting a new standard in dental medicine.
MISSION
​Our mission at Alpha Oral Health is clear: to develop and commercialize a pioneering drug that not only treats periodontitis but aims to eliminate it, ultimately improving both oral and systemic health for millions of patients world-wide.
PERIODONTITIS PREVELANCE:


42% of the US population suffers from Periodontitis and 19% worldwide.
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According to JADA, the Journal of the American Dental Association, an estimated 42% of U.S. adults aged 30 and older are affected by periodontitis. This condition is particularly prevalent in adults aged 65 and older, where the rates of severe periodontitis are highest. The findings from this nationally representative study underscore periodontitis as a common and significant oral health concern among American adults, highlighting the need for continued preventive and therapeutic efforts in dental care across the population.
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“Periodontitis in US Adults.” Eke, Paul I. et al. The Journal of the American Dental Association, Volume 149, Issue 7, 576 - 588.e6.
ECONOMIC IMPACT:

With 80% of the population in the United States suffering from an inflammatory oral condition, the economic impact is staggering.
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The economic impact of periodontal disease is substantial, with an estimated loss of $154.06 billion in the United States. These figures highlight the significant economic burden posed by this prevalent oral disease, encompassing both direct treatment costs and indirect costs related to lost productivity and healthcare expenditures associated with systemic health issues linked to periodontal disease. According to the American Academy of Periodontology, such data reinforces the importance of prioritizing oral health initiatives to mitigate these economic impacts and improve population health outcomes.
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Botelho J, Machado V, Leira Y, Proença L, Chambrone L, Mendes JJ. Economic burden of periodontitis in the United States of America and Europe: An updated estimation. J Periodontol. 2022; 93: 373–379. https://doi.org/10.1002/JPER.21-0111
Periodontal Disease and Its Profound Implications for Systemic Health
Over the years, substantial evidence has emerged establishing a connection between oral diseases and various systemic conditions. Recent research has focused on the intricate interrelationships between oral health, inflammation, and systemic disease. The oral microbiota contributes to localized oral inflammation and can promote systemic inflammation by releasing toxins or facilitating the translocation of microbial products into the bloodstream. This association between oral inflammation and systemic inflammation is crucial for understanding the impact of oral health conditions on multiple organ systems and the potential negative impact of oral diseases to elevate the risk of developing other systemic conditions.
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Systemic conditions that are associated with periodontal disease:
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Neurological conditions such as Alzheimer’s disease and Parkinson's disease
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Autoimmune disorders such as rheumatoid arthritis, lupus, and psoriasis
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Gastrointestinal conditions such as Crohn's disease, irritable bowel syndrome, and ulcerative colitis
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Mental health disorders such as depression and anxiety
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Cardiovascular issues such as high blood pressure and heart disease
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Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD)
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Metabolic disorders such as type 2 diabetes
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Certain cancers
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These findings underscore the critical need for comprehensive dental care as part of an overall health strategy. For further reading on the links between oral health and systemic disease, consider reviewing articles in The Journal of Periodontology.